ANZICS CTG Publications

ANZICS CTG Publications FY2024 – 2025

BEST-DKA

Buffered salt solution versus 0.9% sodium chloride as fluid therapy for patients presenting with moderate to severe diabetic ketoacidosis: Study protocol for a Phase-3 cluster-crossover, blinded, randomised, controlled trial sciencedirect.com/science/article/pii S1441277225000080?via%3Dihub

BLENDER

Conservative or liberal oxygen targets in patients on venoarterial extracorporeal membrane oxygenation. Intensive Care Med. 2024 Sep;50(9):1470-1483. doi: 10.1007/s00134-024-07564-8. Epub 2024 Aug 20. Erratum in: Intensive Care Med. 2024 Dec;50(12):2241-2242. doi: 10.1007/s00134- 024- 07677-0. PMID: 39162827; PMCID: PMC11377512. pubmed.ncbi.nlm.nih.gov/39162827/

DRIVE-RCT NZ

Statistical Power and Performance of Strategies to Analyze Composites of Survival and Duration of Ventilation in Clinical Trials. Crit Care Explor. 2024 Sep pubmed.ncbi.nlm.nih.gov/39302988/

EXCEL Registry

Hospital-level volume in extracorporeal membrane oxygenation cases and death or disability at 6 months. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 26(4), 262– 270. https:/doi.org/10.1016/j.ccrj.2024.08.006

Long-term outcomes of patients who received extracorporeal cardiopulmonary resuscitation (ECPR) following in-hospital cardiac arrest: Analysis of EXCEL registry data. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 26(4), 279–285. doi.org/10.1016/j.ccrj.2024.08.008

Long-Term Functional Outcomes in the First 12 Months After VA-ECMO in Adult Patients: A Prospective, Multicenter Study. Circulation. Heart failure, 18(6), e012476. doi.org/10.1161/circheartfailure.124.012476

Long-term health-related quality of life in survivors of extracorporeal cardiopulmonary resuscitation compared to conventional cardiopulmonary resuscitation- A cohort study using Australian and New Zealand extracorporeal membrane oxygenation registry and the Victorian Ambulance Cardiac Arrest Registry. Resuscitation, 210, 110601. doi.org/10.1016/j.resuscitation.2025.110601

FLASH

Fludrocortisone to treat patients with aneurysmal subarachnoid haemorrhage: Protocol for an international, phase 3, randomised, placebo controlled, multicentre trial doi.org/10.1016/j.ccrj.2025.10011

ICU Resolve-d

Virtual Peer Support for ICU Survivors Is Feasible and May Improve Outcomes for ICU Survivors: Results from the icuRESOLVE-D (icu Recovery Solutions Codesigned through Survivor Engagement–Digital) Pilot Randomized Controlled Trial. American Journal of Respiratory and Critical Care Medicine. 2024 Nov15;210(10):1273-. atsjournals.org/doi/full/10.1164/rccm.202404-0780RL

INTENT

The impact of a tailored nutrition intervention delivered for the duration of hospitalisation on daily energy delivery for patients with critical illness (INTENT): a phase II randomised controlled trial. Crit Care 29, 8 (2025). doi.org/10.1186/s13054-024-05189-3

NUTRIENT

Nutrition delivery during hospitalisation after critical illness in Australia and New Zealand: a multicentre, prospective observational study. DOI: 10.1111/jhn.13385 pubmed.ncbi.nlm.nih.gov/39587763/

REMAP-CAP

The REMAP-CAP Investigators (2025). Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia. link.springer.com/article/10.1007/s00134-025-07861-w

REMAP-CAP Investigators (2025). Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19: a randomised, controlled, open-label, adaptive platform trial. Thorax thorax.bmj.com/content/80/8/530.full

SPRINT-SARI

The relationship between administratively recorded ethnicity and outcomes for people admitted to Australian intensive care units with COVID-19. Aust Crit Care. 2025 Jul;38(4):101228. doi: 10.1016/j.aucc.2025.101228. Epub 2025 Apr 23. PMID: 40273709 https://pubmed.ncbi.nlm.nih.gov/40273709/

In-hospital mortality in patients admitted to Australian intensive care units with COVID-19 between 2020 and 2024. Crit Care Resusc. 2025 Feb 28;27(1):100094. doi: 10.1016/j.ccrj.2024.11.003. PMID: 40109285; PMCID: PMC11919585. researchers.cdu.edu.au/en/publications/in-hospital-mortality-inpatients-admitted-to-australian-intensiv/

Respiratory syncytial virus infection in adult and paediatric patients admitted to intensive care in Australia: A nation-wide comparison with COVID-19. Crit Care Resusc. 2025 June 27;27(2):100113. doi: 10.1016/j.ccrj.2025.100113. pubmed.ncbi.nlm.nih.gov/40677677/

STEPCARE

Sedation, temperature and pressure after cardiac arrest and resuscitation—The STEPCARE trial: A statistical analysis plan, Acta Anaesthesiol Scand. 2025;69:e70033, doi.org/10.1111/aas.70033

Continuous deep sedation versus minimal sedation after cardiac arrest and resuscitation (SED-CARE): A protocol for a randomized clinical trial, Acta Anaesthesiol Scand. 2025;69:e70022, doi.org/10.1111/aas.70022

Fever management with or without a temperature control device after out-of-hospital cardiac arrest and resuscitation (TEMP-CARE): A study protocol for a randomized clinical trial, Acta Anaesthesiol Scand. 2025;69:e70034, doi.org/10.1111/aas.70034

Higher versus lower mean arterial blood pressure after cardiac arrest and resuscitation (MAP-CARE): A protocol for a randomized clinical trial, Acta Anaesthesiol Scand. 2025;69:e70040, https://pubmed.ncbi.nlm.nih.gov/40273709/

TARGET PPP

Nutrition practices in Australia and New Zealand in response to evolving evidence: Results of three point-prevalence audits. Aust Crit Care. 2025 Jan;38(1):101098. doi: 10.1016/j.aucc.2024.07.079. Epub 2024 Aug 23. PMID: 39179491. pubmed.ncbi.nlm.nih.gov/39179491/

TARGET Protein

TARGET Protein Investigators, the Australian, New Zealand Intensive Care Society Clinical Trials Group. TARGET Protein: the effect of augmented administration of enteral protein to critically ill adults on clinical outcomes-statistical analysis plan for a cluster randomized, cross-sectional, double crossover, clinical trial. Trials. 2025 Feb 6;26(1):42. doi: 10.1186/s13063-025-08759-0. PMID: 9915843; PMCID: PMC11800547. pmc.ncbi.nlm.nih.gov/articles/PMC10581259/

Augmented Enteral Protein During Critical Illness: The TARGET Protein Randomized Clinical Trial. JAMA. 2025 Jun 11:e259110. doi: 10.1001/jama.2025.9110. Epub ahead of print. PMID: 40495743; PMCID:PMC12159859. pubmed.ncbi.nlm.nih.gov/40495743/

ANZICS CTG Publications FY2023 – 2024

ANZICS CTG Publications FY2022 – 2023