ANZICS CTG Supported Study
T4P
The Threshold for Platelets study: a prospective randomised trial to define the platelet count below which critically ill patients should receive a platelet transfusion prior to an invasive procedure
Study Description
Prophylactic platelet transfusions are frequently administered to critically ill patients with low platelet counts to reduce the risk of bleeding before they undergo a procedure. However, evidence to support this practice is poor. It is unclear whether pre-procedure prophylactic platelet transfusions reduce bleeding or are otherwise beneficial to ICU patients, and there is evidence that platelet transfusion can cause patient harm. In addition, platelets collected for transfusion are expensive and in limited supply. Aim To define the optimum platelet threshold below which platelets should be transfused prior to an invasive procedure in critically ill patients, and to explore whether the optimum threshold differs according to patient characteristics.
Management Committee
Elissa Milford, Adam Irving, Akshay Shah, Andrew Flint, Belinda Howe, Claire Rickard, Craig French, Dale Trevor, Doug Gould, Ed Litton, Erica Wood, Hayley Noble, James Daly, Kate Wilson, Lisa Higgins, Michael Reade, Peter Wilkinson, Simon Stanworth, Zoe McQuilten, Daisy Lindsay, Christine Brown
Administering Institution
The University of Queensland
Sample size
500
Funding
MRFF, Blood Synergy
Reference
CTG2324-05, ISRCTN79371664
Contact
Elissa Milford (email)