ANZICS CTG Supported Study
STEPCARE
Sedation, Temperature and Pressure after Cardiac Arrest and Resuscitation – The STEPCARE Trial
Study Description
Randomised Controlled Trial
The STEPCARE trial is an international, multicenter, parallel group, non-commercial, randomized, factorial, superiority trial in which sedation, temperature and blood pressure strategies will be studied in patients who have been resuscitated from cardiac arrest and who are unconscious.
3500 patients who are unconscious after cardiac arrest will be included in a trial studying three separate targets. All patients will be randomised to a control or an intervention arm for sedation, temperature and blood pressure targets. These are;
- Continuous deep sedation for 36 hours or minimal sedation
- Fever management with or without a feedback-controlled device
- A mean arterial pressure target of >85mmHg or >65mmHg
Participants will be followed up at 30 days, 6 and 12 months. The primary outcome will be survival at 6 months.
Management Committee
Dr Manoj Saxena, Niklas Nielsen, Prof Anders Aneman, A/Prof Clare Arnott, A/Prof Candice Delcourt, Prof Bala Venkatesh, A/Prof Anthony Delaney, Prof Stephen Bernard, Dr Mahesh Ramanan, Prof Michael Reade, Dr Rakshit Panwar, A/Prof Naomi Hammond, Ms Frances Bass, Dr Serena Knowles, Nyrie Simpson, Chloe Palmer-Simpson
Administering Institution
Australia: The George Institute for Global Health, New Zealand: Medical Research Institute of New Zealand
Sample size
760
Funding
MRFF, Health Research Council of New Zealand
Reference
CCTG2324-02, NCT05564754
Contact
Manoj Saxena (email)