ANZICS CTG supported Study

DRIVE RCT- Australia

DRIVing PrEssure Limited Ventilation in Hypoxemic Respiratory Failure–Randomised Control Trial

Study Description

Multi-national, Allocation-concealed, Open-label, Bayesian adaptive, Randomized Controlled Trial.

Patients with Acute Hypoxemic Respiratory Failure are vulnerable to nosocomial complications of critical care, and lung and diaphragm injury associated with mechanical ventilation.

Driving pressure, the elastic pressure generated by inflating the respiratory system with the tidal volume (Vt), reflects the stress applied to the lung.  Driving pressure remains high in many patients even when Vt is in the protective range, especially in those with high respiratory system elastance.

A new non-invasive technique allows us to easily detect high driving pressure due to patient breathing effort. A ventilator-based technique (expiratory occlusion pressure, Pocc) can measure the patient’s respiratory effort and this information can be used to compute the lung-distending pressure (dynamic transpulmonary driving pressure).

This trial aims to determine the effect of a driving pressure-limited ventilation strategy in comparison to conventional tidal volume limited ventilation in patients receiving invasive mechanical ventilation for acute hypoxemic respiratory failure

For more information about PRACTICAL go to:

Home | PRACTICAL Platform

Management Committee

Prof Carol Hodgson ANZIC Research Centre Monash University, Prof Ary Serpa Neto ANZIC Research Centre Monash University, A/Prof Ian Seppelt Nepean Hospital, A/Prof David Gattas Sydney Local Health District, Dr Peter Kruger Metro South Hospital and Health Service, Prof Steve Webb ANZIC Research Centre Monash University, Prof Sandra Peake Central Adelaide Local Health Network, Prof Alistair Nichol ANZIC Research Centre Monash University, Dr Lisa Higgins ANZIC Research Centre Monash University, Dr Idunn Morris, Nepean Hospital, A/Prof Neil Orford Deakin University, Dr Anais Charles-Nelson ANZIC Research Centre Monash University, Ms Heidi Buhr Royal Prince Alfred Hospital, Ms Rebecca Morgan ANZIC Research Centre Monash University, Ms Shannah Anderson Consumer Representative, Mrs Pamela Taylor Consumer Representative,

Administering Institution

ANZIC RC Monash University

Sample size

360

Funding

NHMRC MRFF CTA, Collaborative agreement with University Health Network, Toronto. Funding body CIHR

Reference

CTG2223-04, NCT05440851

Contact

Carol Hodgson (email), Rebecca Morgan (email), Ary Serpa Neto (email)