ANZICS CTG endorsed Study

BEST-DKA

Balanced multi-electrolyte solution versus 0.9% sodium chloride as fluid therapy for patients presenting with moderate to severe diabetic ketoacidosis

Study Description

Blinded, cluster-crossover, randomised controlled trial in emergency and Intensive care departments.

To determine whether fluid therapy with Plasma-Lyte® 148 increases the number of days alive and days out of hospital to day-28 compared to 0.9% sodium chloride (‘0.9% saline’) in critically ill patients presenting to the Emergency Department (ED) and deemed to require admission to a critical care area (ICU, HDU) with moderate to severe diabetic ketoacidosis (DKA)

Management Committee

Prof Bala Venkatesh, Dr Mahesh Ramanan (Co-Chair/Deputy Chair), A/Prof Jeremy Cohen, Prof Sandra Peake, A/Prof Anthony Delaney, Elif Ekinci, Dr Gerben Keijzer, A/Prof Lisa Higgins, Prof Anthony Russell, Dr Benjamin Moran, Prof Simon Finfer, Prof John Myburgh, Dr Serena Knowles, A/Prof Naomi Hammond, Ms Dorrilyn Rajbhandari, Ms Stacey Watts

Administering Institution

The George Institute

Sample size

480

Funding

MRFF, Baxter, Diabetes Australia

Reference

CTG2324-03, NCT05752279

Contact

Mahesh Ramanan (email)