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Publications

2020
Relative Hypotension and Adverse Kidney-related Outcomes Among Critically Ill Patients with Shock- A Multicenter Prospective Cohort Study

Rakshit Panwar, Sanjay Tarvade, Nicholas Lanyon, Manoj Saxena, Dustin Bush, Miranda Hardie, John Attia, Rinaldo Bellomo, Frank Van Haren on behalf of the REACT Shock Study Investigators and the ANZICS Clinical Trials Group

Am J Respir Crit Care Med. 2020;10.1164/rccm.201912-2316OC. [published online ahead of print, 2020 Jul 2]
The Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia (REMAP-CAP) Study: Rationale and Design

Angus DC, Berry S, Lewis RJ, Al-Beidh F, Arabi Y, van Bentum-Puijk W, Bhimani Z, Bonten M, Broglio K, Brunkhorst F, Cheng AC, Chiche JD, De Jong M, Detry M, Goossens H, Gordon A, Green C, Higgins AM, Hullegie SJ, Kruger P, Lamontagne F, Litton E, Marshall J, McGlothlin A, McGuinness S, Mouncey P, Murthy S, Nichol A, O'Neill GK, Parke R, Parker J, Rohde G, Rowan K, Turner A, Young P, Derde L, McArthur C, Webb SA.

Ann Am Thorac Soc. 2020 Apr 8. doi: 10.1513/AnnalsATS.202003-192SD. [Epub ahead of print] PubMed PMID: 32267771
Protocol for outcome reporting and follow-up in the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest trial (TTM2)

Lilja G, Nielsen N, Ullén S, Blennow Nordstrom E, Dankiewicz J, Friberg H, Heimburg K, Jakobsen JC, Levin H, Callaway C, Cariou A, Eastwood GM, Helbok R, Hovdenes J, Kirkegaard H, Leithner C, Morgan MPG, Nordberg P, Oddo M, Pelosi P, Rylander C, Saxena M, Taccone FS, Siranec M, Wise MP, Young PJ, Cronberg T.

Resuscitation. 2020 Mar 20;150:104-112. doi: 10.1016/j.resuscitation.2020.03.004. [Epub ahead of print] PubMed PMID: 32205155
Predicting treatment benefit in children with sepsis treated with extracorporeal life support – a binational multicenter retrospective cohort study.

Schlapbach LJ, Chiletti R, Straney L, et al.

Crit Care 2020 in press
Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial

PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group, Young PJ, Bagshaw SM, Forbes AB, Nichol AD, Wright SE, Bailey M, Bellomo R, Beasley R, Brickell K, Eastwood GM, Gattas DJ, van Haren F, Litton E, Mackle DM, McArthur CJ, McGuinness SP, Mouncey PR, Navarra L, Opgenorth D, Pilcher D, Saxena MK, Webb SA, Wiley D, Rowan KM.

JAMA. 2020 Jan 17. doi: 10.1001/jama.2019.22190. [Epub ahead of print] PubMed PMID: 31950977.
2019
Defining benefit threshold for extracorporeal membrane oxygenation in children with sepsis-a binational multicenter cohort study

Schlapbach LJ, Chiletti R, Straney L, Festa M, Alexander D, Butt W, MacLaren G; Australian & New Zealand Intensive Care Society (ANZICS) Centre for Outcomes & Resource Evaluation (CORE) and the Australian & New Zealand Intensive Care Society (ANZICS) Paediatric Study Group.

Crit Care. 2019 Dec 30;23(1):429. doi: 10.1186/s13054-019-2685-1. PubMed PMID: 31888705; PubMed Central PMCID: PMC6937937
Conservative oxygen therapy for mechanically ventilated adults with sepsis: a post hoc analysis of data from the intensive care unit randomized trial comparing two approaches to oxygen therapy (ICU-ROX)

Young P, Mackle D, Bellomo R, Bailey M, Beasley R, Deane A, Eastwood G, Finfer S, Freebairn R, King V, Linke N, Litton E, McArthur C, McGuinness S, Panwar R; ICU-ROX Investigators the Australian New Zealand Intensive Care Society Clinical Trials Group.

Intensive Care Med. 2020 Jan;46(1):17-26. doi: 10.1007/s00134-019-05857-x. Epub 2019 Nov 20. PubMed PMID: 31748836
Conservative Oxygen Therapy during Mechanical Ventilation in the ICU

ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group, Mackle D, Bellomo R, Bailey M, Beasley R, Deane A, Eastwood G, Finfer S, Freebairn R, King V, Linke N, Litton E, McArthur C, McGuinness S, Panwar R, Young P.

N Engl J Med. 2019 Oct 14. doi: 10.1056/NEJMoa1903297. [Epub ahead of print] PubMed PMID: 31613432.
Randomised evaluation of active control of temperature versus ordinary temperature management (REACTOR) trial

Young PJ, Bailey MJ, Bass F, Beasley RW, Freebairn RC, Hammond NE, van Haren FMP, Harward ML, Henderson SJ, Mackle DM, McArthur CJ, McGuinness SP, Myburgh JA, Saxena MK, Turner AM, Webb SAR, Bellomo R; REACTOR investigators; ANZICS Clinical Trials Group.

Intensive Care Med. 2019 Oct;45(10):1382-1391. doi: 10.1007/s00134-019-05729-4. Epub 2019 Oct 1. PubMed PMID: 31576434.
Study protocol: NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC trial): a randomised controlled trial.

Schlapbach LJ, Horton SB, Long DA, Beca J, Erickson S, Festa M, d'Udekem Y, Alphonso N, Winlaw D, Johnson K, Delzoppo C, van Loon K, Gannon B, Fooken J, Blumenthal A, Young P, Jones M, Butt W, Schibler A; NITRIC Study Group, the Australian and New Zealand Intensive Care Society Clinical Trials Group (ANZICS CTG), the Paediatric Critical Care Research group (PCCRG) and the ANZICS Paediatric Study Group (PSG)

BMJ Open. 2019 Aug 15;9(8):e026664. doi: 10.1136/bmjopen-2018-026664
Maximal Recruitment Open Lung Ventilation in Acute Respiratory Distress Syndrome (PHARLAP): A Phase II, Multicenter, Randomized, Controlled Trial

Hodgson CL, Cooper DJ, Arabi Y, King V, Bersten A, Bihari S, Brickell K, Davies A, Fahey C, Fraser J, McGuinness S, Murray L, Parke R, Paul E, Tuxen D, Vallance S, Young M, Nichol A; PHARLAP Study Investigators and the ANZICS Clinical Trials Group

Am J Respir Crit Care Med. 2019 Jul 29. doi: 10.1164/rccm.201901-0109OC. [Epub ahead of print] PubMed PMID: 31356105.
Epidemiology of childhood death in Australian and New Zealand intensive care units.

Moynihan KM, Alexander PMA, Schlapbach LJ, Millar J, Jacobe S, Ravindranathan H, Croston EJ, Staffa SJ, Burns JP, Gelbart B; Australian and New Zealand Intensive Care Society Pediatric Study Group (ANZICS PSG) and the ANZICS Centre for Outcome and Resource Evaluation (ANZICS CORE).

Intensive Care Med. 2019 Sep;45(9):1262-1271. doi: 10.1007/s00134-019-05675-1. Epub 2019 Jul 3. PubMed PMID: 31270578.
Quality of Life and 1-Year Survival in Patients With Early Septic Shock: Long-Term Follow-Up of the Australasian Resuscitation in Sepsis Evaluation Trial

Higgins AM, Peake SL, Bellomo R, Cooper DJ, Delaney A, Harris AH, Howe BD, Nichol AD, Webb SA, Williams PJ; Australasian Resuscitation in Sepsis Evaluation (ARISE) Investigators and the ANZICS Clinical Trials Group

Crit Care Med. 2019 Jun;47(6):765-773. doi: 10.1097/CCM.0000000000003762. PubMed PMID: 30985391.
Early Sedation with Dexmedetomidine in Critically Ill Patients

Shehabi Y, Howe BD, Bellomo R, Arabi YM, Bailey M, Bass FE, Bin Kadiman S, McArthur CJ, Murray L, Reade MC, Seppelt IM, Takala J, Wise MP, Webb SA; ANZICS Clinical Trials Group and the SPICE III Investigators

N Engl J Med. 2019 Jun 27;380(26):2506-2517. doi: 10.1056/NEJMoa1904710. Epub 2019 May 19. PubMed PMID: 31112380
Global paediatric critical care research: mind the gaps.

Schlapbach LJ, Gelbart B, Festa M; Australian & New Zealand Intensive Care Society Paediatric Study Group (ANZICS PSG), Kanthimathinathan HK, Peters MJ.

Intensive Care Med. 2019 May;45(5):753-754. doi: 10.1007/s00134-019-05571-8. Epub 2019 Mar 6. No abstract available.
A protocol for a phase 3 multicentre randomised controlled trial of continuous versus intermittent β-lactam antibiotic infusion in critically ill patients with sepsis: BLING III

Lipman J, Brett SJ, De Waele JJ, Cotta MO, Davis JS, Finfer S, Glass P, Knowles S, McGuinness S, Myburgh J, Paterson DL, Peake S, Rajbhandari D, Rhodes A, Roberts JA, Shirwadkar C, Starr T, Taylor C, Billot L, Dulhunty JM

Crit Care Resusc. 2019 Mar;21(1):63-68. PubMed PMID: 30857514.
Transnasal Humidified Rapid Insufflation Ventilatory Exchange in children requiring emergent intubation (Kids THRIVE): a protocol for a randomised controlled trial.

George S, Humphreys S, Williams T, Gelbart B, Chavan A, Rasmussen K, Ganeshalingham A, Erickson S, Ganu SS, Singhal N, Foster K, Gannon B, Gibbons K, Schlapbach LJ, Festa M, Dalziel S, Schibler A; Paediatric Critical Care Research Group (PCCRG), Paediatric Research in Emergency Departments International Collaborative (PREDICT) and the Australia and New Zealand Intensive Care Society Paediatric Study Group (ANZICS PSG).

BMJ Open. 2019 Feb 20;9(2):e025997. doi: 10.1136/bmjopen-2018-025997.
2018
Incidence, Patient Characteristics, Mode of Drug Delivery, and Outcomes of Septic Shock Patients Treated with Vasopressors in the ARISE Trial.

Udy AA, Finnis M, Jones D, Delaney A, Macdonald S, Bellomo R, Peake S; ARISE Investigators.

Shock. 2018 Oct 30. doi: 10.1097/SHK.0000000000001281. [Epub ahead of print] PubMed PMID: 30379749.
Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial.

Cooper DJ, Nichol AD, Bailey M, Bernard S, Cameron PA, Pili-Floury S, Forbes A, Gantner D, Higgins AM, Huet O, Kasza J, Murray L, Newby L, Presneill JJ, Rashford S, Rosenfeld JV, Stephenson M, Vallance S, Varma D, Webb SAR, Trapani T, McArthur C; POLAR Trial Investigators and the ANZICS Clinical Trials Group.

JAMA. 2018 Oct 24. doi: 10.1001/jama.2018.17075. [Epub ahead of print] PubMed PMID: 30357266.
Energy-Dense versus Routine Enteral Nutrition in the Critically Ill.

TARGET Investigators, for the ANZICS Clinical Trials Group.

N Engl J Med. 2018 Oct 22. doi: 10.1056/NEJMoa1811687. [Epub ahead of print] PubMed PMID: 30346225.
A cross-sectional survey of Australian and New Zealand public opinion on methods to triage intensive care patients in an influenza pandemic.

Cheung W, Myburgh J, McGuinness S, et al. on behalf of the Influenza Pandemic ICU Triage 3 study investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group.

Critical Care and Resuscitation Sept 2017 Edition.
A cluster randomised, crossover, registry-embedded clinical trial of proton pump inhibitors versus histamine-2 receptor blockers for ulcer prophylaxis therapy in the intensive care unit (PEPTIC study): study protocol.

Young PJ, Bagshaw SM, Forbes A, Nichol A, Wright SE, Bellomo R, Bailey MJ, Beasley RW, Eastwood GM, Festa M, Gattas D, van Haren F, Litton E, Mouncey PR, Navarra L, Pilcher D, Mackle DM, McArthur CJ, McGuinness SP, Saxena MK, Webb S, Rowan KM; Australian and New Zealand Intensive Care Society Clinical Trials Group on behalf of the PEPTIC investigators.

Crit Care Resusc. 2018 Sep;20(3):182-189. PubMed PMID: 30153780.
Hepcidin predicts response to IV iron therapy in patients admitted to the intensive care unit: a nested cohort study.

Litton E, Baker S, Erber W, Farmer S, Ferrier J, French C, Gummer J, Hawkins D, Higgins A, Hofmann A, De Keulenaer B, McMorrow J, Olynyk JK, Richards T, Towler S, Trengove R, Webb S; IRONMAN Study Investigators; Australian and New Zealand Intensive Care Society Clinical Trials Group.

J Intensive Care. 2018 Sep 10;6:60. doi: 10.1186/s40560-018-0328-2. eCollection 2018. PubMed PMID: 30214812; PubMed Central PMCID: PMC6131742.
The relationship between the change in central venous pressure and intravenous fluid volume in patients presenting to the emergency department with septic shock.

Reddi B, Finnis M, Udy AA, Maiden M, Delaney A, Bellomo R, Peake S; ARISE Study Management Committee and the Australian and New Zealand Intensive Care Society Clinical Trials Group.

Intensive Care Med. 2018 Sep;44(9):1591-1592. doi: 10.1007/s00134-018-5314-6. Epub 2018 Jul 20. PubMed PMID: 30030572.
Erythropoietin in traumatic brain injury associated acute kidney injury: A randomized controlled trial

Skrifvars MB, Moore E, Mårtensson J, Bailey M, French C, Presneill J, Nichol A, Little L, Duranteau J, Huet O, Haddad S, Arabi Y, McArthur C, Cooper DJ, Bellomo R; EPO-TBI Investigators and the ANZICS Clinical Trials Group

Acta Anaesthesiol Scand. 2019 Feb;63(2):200-207. doi: 10.1111/aas.13244. Epub 2018 Aug 21. PubMed PMID: 30132785
Secretion clearance strategies in Australian and New Zealand Intensive Care Units.

Ntoumenopoulos G, Hammond N, Watts NR, Thompson K, Hanlon G, Paratz JD, Thomas P; George Institute for Global Health and the Australian and New Zealand Intensive Care Society Clinical Trials Group.

Aust Crit Care. 2018 Jul;31(4):191-196. doi: 10.1016/j.aucc.2017.06.002. Epub 2017 Jun 27.
Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery.

Myles PS, Bellomo R, Corcoran T, Forbes A, Peyton P, Story D, Christophi C, Leslie K, McGuinness S, Parke R, Serpell J, Chan MTV, Painter T, McCluskey S, Minto G, Wallace S; Australian and New Zealand College of Anaesthetists Clinical Trials Network and the Australian and New Zealand Intensive Care Society Clinical Trials Group.

N Engl J Med. 2018 Jun 14;378(24):2263-2274. doi: 10.1056/NEJMoa1801601. Epub 2018 May 9.
Permissive Hypercapnia, Alveolar Recruitment and Low Airway Pressure (PHARLAP): a protocol for a phase 2 trial in patients with acute respiratory distress syndrome.

Hodgson C, Cooper DJ, Arabi Y, Bennett V, Bersten A, Brickell K, Davies A, Fahey C, Fraser J, McGuinness S, Murray L, Parke R, Tuxen D, Vallance S, Young M, Nichol AD; PHARLAP Study Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group.

Crit Care Resusc. 2018 Jun;20(2):139-149.
Sedation Intensity in the First 48 Hours of Mechanical Ventilation and 180-Day Mortality: A Multinational Prospective Longitudinal Cohort Study.

Shehabi Y, Bellomo R, Kadiman S, Ti LK, Howe B, Reade MC, Khoo TM, Alias A, Wong YL, Mukhopadhyay A, McArthur C, Seppelt I, Webb SA, Green M, Bailey MJ; Sedation Practice in Intensive Care Evaluation (SPICE) Study Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group.

Crit Care Med. 2018 Jun;46(6):850-859. doi: 10.1097/CCM.0000000000003071.
Statistical analysis plan for the POLAR-RCT: The Prophylactic hypOthermia trial to Lessen trAumatic bRain injury-Randomised Controlled Trial.

Presneill J, Gantner D, Nichol A, McArthur C, Forbes A, Kasza J, Trapani T, Murray L, Bernard S, Cameron P, Capellier G, Huet O, Newby L, Rashford S, Rosenfeld JV, Smith T, Stephenson M, Varma D, Vallance S, Walker T, Webb S, James Cooper D; POLAR investigators and the ANZICS Clinical Trials Group.

Trials. 2018 Apr 27;19(1):259. doi: 10.1186/s13063-018-2610-y.
SOFA coagulation score and changes in platelet counts in severe acute kidney injury: analysis from the Randomised Evaluation of Normal versus Augmented Level (RENAL) study.

Lin J, Gallagher M, Bellomo R, Duan M, Trongtrakul K, Wang AY; RENAL Study Investigators and the ANZICS Clinical Trials Group.

Nephrology (Carlton). 2018 Apr 24. doi: 10.1111/nep.13387. [Epub ahead of print]
Endotracheal suction in intensive care: A point prevalence study of current practice in New Zealand and Australia.

Gilder E, Parke RL, Jull A; Australian and New Zealand Intensive Care Society Clinical Trials Group and The George Institute for Global Health.

Aust Crit Care. 2018 Apr 14. pii: S1036-7314(17)30352-1. doi: 10.1016/j.aucc.2018.03.001. [Epub ahead of print]
Protocol summary and statistical analysis plan for the intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX).

Mackle DM, Bailey MJ, Beasley RW, Bellomo R, Bennett VL, Deane AM, Eastwood GM, Finfer S, Freebairn RC, Litton E, Linke NJ, McArthur CJ, McGuinness SP, Panwar R, Young PJ; Australian and New Zealand Intensive Care Society Clinical Trials Group.

Crit Care Resusc. 2018 Mar;20(1):22-32.
Erythropoietin to Reduce Mortality in Traumatic Brain Injury: A Post-hoc Dose-effect Analysis.

Gantner DC, Bailey M, Presneill J, French CJ, Nichol A, Little L, Bellomo R; EPO-TBI Investigators; and the ANZICS Clinical Trials Group.

Ann Surg. 2018 Mar;267(3):585-589. doi: 10.1097/SLA.0000000000002142.
Smoking cessation therapy in Australian and New Zealand intensive care units: a multicentre point prevalence study.

McGain F, Durie ML, Bates S, Polmear CM, Meyer J, French CJ; George Institute for Global Health and the Australian and New Zealand Intensive Care Society Clinical Trials Group.

Crit Care Resusc. 2018 Mar;20(1):68-73.
Statistical analysis plan for the Augmented versus Routine Approach to Giving Energy Trial (TARGET).

TARGET Investigators on behalf of the Australian and New Zealand Intensive Care Society Clinical Trials Group.

Crit Care Resusc. 2018, Mar;20(1):15-21.
Study protocol for the Augmented versus Routine Approach to Giving Energy Trial (TARGET).

TARGET Investigators on behalf of the Australian and New Zealand Intensive Care Society Clinical Trials Group.

Crit Care Resusc. 2018 Mar;20(1):6-14.
Day or overnight transfusion in critically ill patients: does it matter?

Aubron C, Kandane-Rathnayake RK, Andrianopoulos N, Westbrook A, Engelbrecht S, Ozolins I, Bailey M, Murray L, Cooper DJ, Wood EM, McQuilten ZK; Blood Observational Study investigators; ANZICS Clinical Trials Group.

Vox Sang. 2018 Apr;113(3):275-282. doi: 10.1111/vox.12635. Epub 2018 Feb 2.
Adjunctive Glucocorticoid Therapy in Patients with Septic Shock.

Venkatesh B, Finfer S, Cohen J, Rajbhandari D, Arabi Y, Bellomo R, Billot L, Correa M, Glass P, Harward M, Joyce C, Li Q, McArthur C, Perner A, Rhodes A, Thompson K, Webb S, Myburgh J; ADRENAL Trial Investigators and the Australian–New Zealand Intensive Care Society Clinical Trials Group.

N Engl J Med. 2018 Mar 1;378(9):797-808. doi: 10.1056/NEJMoa1705835. Epub 2018 Jan 19.
Six-Month Outcomes After High-Risk Coronary Artery Bypass Graft Surgery and Preoperative Intra-aortic Balloon Counterpulsation Use: An Inception Cohort Study.

Litton E, Bass F, Delaney A, Hillis G, Marasco S, McGuinness S, Myles PS, Reid CM, Smith JA; PINBALL study investigators and the ANZICS CTG.

J Cardiothorac Vasc Anesth. 2018 Jan 5. pii: S1053-0770(18)30008-9. doi: 10.1053/j.jvca.2018.01.005. [Epub ahead of print]
2017
Intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX): results of the pilot phase.

Young PJ, Mackle DM, Bailey MJ, Beasley RW, Bennett VL, Deane AM, Eastwood GM, Finfer S, Freebairn RC, Litton E, Linke NJ, McArthur CJ, McGuinness SP, Panwar R, Bellomo R; The ICU-ROX pilot investigators; The Australian and New Zealand Intensive Care Society Clinical Trials Group.

Crit Care Resusc. 2017 Dec;19(4):344-354.
The SPICE III study protocol and analysis plan: a randomised trial of early goaldirected sedation compared with stand-ard care in mechanically ventilated patients.

Shehabi Y, Forbes AB, Arabi Y, Bass F, Bellomo R, Kadiman S, Howe BD, McArthur C, Reade MC, Seppelt I, Takala J, Webb S, Wise MP; The SPICE III study investigators; The Australian and New Zealand Intensive Care Society Clinical Trials Group; The Australian and New Zealand Intensive Care Research Centre.

Crit Care Resusc. 2017 Dec;19(4):318-326.
Maintenance fluid practices in paediatric intensive care units in Australia and New Zealand.

Bihari S, Gelbart B, Seppelt I, Thompson K, Watts N, Prakash S, Festa M, Bersten A; The George Institute for Global Health; The Australian and New Zealand Intensive Care Society Clinical Trials Group.

Crit Care Resusc. 2017 Dec;19(4):310-317.
Higher versus Lower Continuous Renal Replacement Therapy Intensity in Critically ill Patients with Liver Dysfunction.

O’Brien Z, Cass A, Cole L, Finfer S, Gallagher M, McArthur C, McGuiness S, Myburgh J, Bellomo R, Mårtensson J; RENAL Study Investigators and the Australian and New Zealand Intensive Care Clinical Trials Group.

Blood Purif. 2017 Nov 22;45(1-3):36-43. doi: 10.1159/000480224. [Epub ahead of print]
Erythropoietin in patients with traumatic brain injury and extracranial injury-A post hoc analysis of the erythropoietin traumatic brain injury trial.

Skrifvars MB, Bailey M, French C, Presneill J, Nichol A, Little L, Duranteau J, Huet O, Haddad S, Arabi Y, McArthur C, Cooper DJ, Bellomo R; EPO-TBI investigators and the ANZICS Clinical Trials Group.

J Trauma Acute Care Surg. 2017 Sep;83(3):449-456. doi: 10.1097/TA.0000000000001594.
Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults

Cooper DJ, McQuilten ZK, Nichol A, Ady B, Aubron C, Bailey M, Bellomo R, Gantner D, Irving DO, Kaukonen KM, McArthur C, Murray L, Pettilä V, French C; TRANSFUSE Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group.

N Engl J Med. 2017 Nov 9;377(19):1858-1867. doi: 10.1056/NEJMoa1707572. Epub 2017 Sep 27. PubMed PMID: 28952891.
Prediction of pediatric sepsis mortality within 1 h of intensive care admission.

Schlapbach LJ, MacLaren G, Festa M, Alexander J, Erickson S, Beca J, Slater A, Schibler A, Pilcher D, Millar J, Straney L; Australian & New Zealand Intensive Care Society (ANZICS) Centre for Outcomes & Resource Evaluation (CORE) and Australian & New Zealand Intensive Care Society (ANZICS) Paediatric Study Group.

Intensive Care Med. 2017 Aug;43(8):1085-1096. doi: 10.1007/s00134-017-4701-8. Epub 2017 Feb 20.
Using Clinically Accessible Tools to Measure Sound Levels and Sleep Disruption in the ICU: A Prospective Multicenter Observational Study.

Litton E, Elliott R, Thompson K, Watts N, Seppelt I, Webb SAR; ANZICS Clinical Trials Group and The George Institute for Global Health.

Crit Care Med. 2017 Jun;45(6):966-971. doi: 10.1097/CCM.0000000000002405. PubMed PMID: 28362644.
Burden of disease and change in practice in critically ill infants with bronchiolitis.

Schlapbach LJ, Straney L, Gelbart B, Alexander J, Franklin D, Beca J, Whitty JA, Ganu S, Wilkins B, Slater A, Croston E, Erickson S, Schibler A; Australian & New Zealand Intensive Care Society (ANZICS) Centre for Outcomes & Resource Evaluation (CORE) and the Australian & New Zealand Intensive Care Society (ANZICS) Paediatric Study Group.

Eur Respir J. 2017 Jun 1;49(6). pii: 1601648. doi: 10.1183/13993003.01648-2016. Print 2017 Jun.
Association between augmented renal clearance and clinical outcomes in patients receiving β-lactam antibiotic therapy by continuous or intermittent infusion: a nested cohort study of the BLING-II randomised, placebo-controlled, clinical trial.

Udy AA, Dulhunty JM, Roberts JA, Davis JS, Webb SAR, Bellomo R, Gomersall C, Shirwadkar C, Eastwood GM, Myburgh J, Paterson DL, Starr T, Paul SK, Lipman J; BLING-II Investigators; ANZICS Clinical Trials Group.

Int J Antimicrob Agents. 2017 May;49(5):624-630. doi: 10.1016/j.ijantimicag.2016.12.022. Epub 2017 Mar 9. PubMed PMID: 28286115.
The Australian and New Zealand Intensive Care Society Clinical Trials Group point prevalence program, 2009-2016.

Thompson K, Hammond N, Eastwood G, Festa M, Glass P, Rajbhandari D, Seppelt I, Taylor C, Watts N, Myburgh J; The Point Prevalence Program Management Committee; The Australian and New Zealand Intensive Care Society Clinical Trials Group; The George Institute for Global Health.

Crit Care Resusc. 2017 Mar;19(1):88-93. PubMed PMID: 28215137.
Protocol and statistical analysis plan for the Randomised Evaluation of Active Control of Temperature versus Ordinary Temperature Management (REACTOR) trial.

Young PJ, Bailey MJ, Beasley RW, Freebairn RC, Hammond NE, Haren FM, Harward ML, Henderson SJ, Mackle DM, McArthur CJ, McGuinness SP, Myburgh JA, Saxena MK, Turner A, Webb SA, Bellomo R; The ANZICS Clinical Trials Group.

Crit Care Resusc. 2017 Mar;19(1):81-87. PubMed PMID: 28215136.
The burden of invasive infections in critically ill Indigenous children in Australia.

Ostrowski JA, MacLaren G, Alexander J, Stewart P, Gune S, Francis JR, Ganu S, Festa M, Erickson SJ, Straney L, Schlapbach LJ.

Med J Aust. 2017 Feb 6;206(2):78-84.
2016
Venous thromboembolic events in critically ill traumatic brain injury patients.

Skrifvars MB, Bailey M, Presneill J, French C, Nichol A, Little L, Duranteau J, Huet O, Haddad S, Arabi Y, McArthur C, Cooper DJ, Bellomo R; EPO-TBI investigators and the ANZICS Clinical Trials Group.

Intensive Care Med. 2017 Mar;43(3):419-428. doi: 10.1007/s00134-016-4655-2. Epub 2016 Dec 27. PubMed PMID:28028552.
Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial : A randomized trial of IV iron in critical illness.

IRONMAN Investigators., Litton E, Baker S, Erber WN, Farmer S, Ferrier J, French C, Gummer J, Hawkins D, Higgins A, Hofmann A, De Keulenaer B, McMorrow J, Olynyk JK, Richards T, Towler S, Trengove R, Webb S; Australian and New Zealand Intensive Care Society Clinical Trials Group.

Intensive Care Med. 2016 Nov;42(11):1715-1722. PubMed PMID: 27686346.
Burden and Outcomes of Severe Pertussis Infection in Critically Ill Infants.

Straney L, Schibler A, Ganeshalingham A, Alexander J, Festa M, Slater A, MacLaren G, Schlapbach LJ; Australian and New Zealand Intensive Care Society Centre for Outcomes and Resource Evaluation and the Australian and New Zealand Intensive Care Society Paediatric Study Group.

Pediatr Crit Care Med. 2016 Aug;17(8):735-42. doi: 10.1097/PCC.0000000000000851.
Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium: A Randomized Clinical Trial.

Reade MC, Eastwood GM, Bellomo R, Bailey M, Bersten A, Cheung B, Davies A, Delaney A, Ghosh A, van Haren F, Harley N, Knight D, McGuiness S, Mulder J, O'Donoghue S, Simpson N, Young P; DahLIA Investigators; Australian and New Zealand Intensive Care Society Clinical Trials Group.

JAMA. 2016 Apr 12;315(14):1460-8. doi: 10.1001/jama.2016.2707. PubMed PMID: 26975647
Is inhaled prophylactic heparin useful for prevention and Management of Pneumonia in ventilated ICU patients?: The IPHIVAP investigators of the Australian and New Zealand Intensive Care Society Clinical Trials Group.

Hiran Bandeshe, Rob Boots, Joel Dulhunty, Rachael Dunlop, Anthony Holley, Paul Jarrett, Charles D. Gomersall, Jeff Lipman, Thomas Lo, Steven O'Donoghue, Jenny Paratz, David Paterson, Jason A. Roberts, Therese Starr, Di Stephens, Janine Stuart, Jane Thomas, Andrew Udy, Hayden White.

Crit Care Med. 2016. April 9 [Epub ahead of print]. 95–102.
A Binational Multicenter Pilot Feasibility Randomized Controlled Trial of Early Goal-Directed Mobilization in ICU.

Hodgson CL, Bailey M, Bellomo R, Berney S, Buhr H, Denehy L, Gabbe B, Harrold M, Higgins A, Iwashyna TJ, Papworth R, Parke R, Patman S, Presneill J, Saxena M, Skinner E, Tipping C, Young P, Webb S; Trial of Early Activity and Mobilization Study Investigators.

Crit Care Med. 2016 Mar 10. [Epub ahead of print] PubMed PMID: 26968024.
Hospital overnight and evaluation of systems and timelines study: A point prevalence study of practice in Australia and New Zealand.

Sundararajan K, Flabouris A, Thompson C, Seppelt I; George Institute of Global Health; Australian and New Zealand Intensive Care Society Clinical Trials Group Point Prevalence Study Investigators

Resuscitation. 2016 Mar;100:1-5. doi: 10.1016/j.resuscitation.2015.11.029. Epub 2015 Dec 31. PMID: 26748146
Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries.

Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, Ranieri M, Rubenfeld G, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group.

JAMA. 2016 Feb 23;315(8):788-800. doi: 10.1001/jama.2016.0291. PubMed PMID: 26903337.
Conservative versus Liberal Oxygenation Targets for Mechanically Ventilated Patients. A Pilot Multicenter Randomized Controlled Trial.

Panwar R, Hardie M, Bellomo R, Barrot L, Eastwood GM, Young PJ, Capellier G, Harrigan PW, Bailey M; CLOSE Study Investigators; ANZICS Clinical Trials Group.

Am J Respir Crit Care Med. 2016 Jan 1;193(1):43-51. doi: 10.1164/rccm.201505-1019OC. PubMed PMID: 26334785.
2015
A Multicenter Randomized Trial of Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis.

Dulhunty JM, Roberts JA, Davis JS, Webb SA, Bellomo R, Gomersall C, Shirwadkar C, Eastwood GM, Myburgh J, Paterson DL, Starr T, Paul SK, Lipman J; BLING II Investigators for the ANZICS Clinical Trials Group *.

Am J Respir Crit Care Med. 2015 Dec 1;192(11):1298-305. doi: 10.1164/rccm.201505-0857OC. PubMed PMID: 26200166.
Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit: The SPLIT Randomized Clinical Trial.

Young P, Bailey M, Beasley R, Henderson S, Mackle D, McArthur C, McGuinness S, Mehrtens J, Myburgh J, Psirides A, Reddy S, Bellomo R; SPLIT Investigators; ANZICS CTG.

JAMA. 2015 Oct 27;314(16):1701-10. doi: 10.1001/jama.2015.12334. PubMed PMID: 26444692.
Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial.

Nichol A, French C, Little L, Haddad S, Presneill J, Arabi Y, Bailey M, Cooper DJ, Duranteau J, Huet O, Mak A, McArthur C, Pettilä V, Skrifvars M, Vallance S, Varma D, Wills J, Bellomo R; EPO-TBI Investigators and the ANZICS Clinical Trials Group.

Lancet. 2015 Oct 6. pii: S0140-6736(15)00386-4. doi: 10.1016/S0140-6736(15)00386-4. [Epub ahead of print] PubMed PMID: 26452709.
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.

Young P, Saxena M, Bellomo R, Freebairn R, Hammond N, van Haren F, Holliday M, Henderson S, Mackle D, McArthur C, McGuinness S, Myburgh J, Weatherall M, Webb S, Beasley R; HEAT Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group.

N Engl J Med. 2015 Oct 5. [Epub ahead of print] PubMed PMID: 26436473.
Epidemiology of Paediatric Chronic Critical Illness in Australia and New Zealand.

Siva Namachivayam, Janet Alexander, Anthony Slater, Johnny Millar, Simon Erickson, James Tibballs, Marino Festa, Subodh Ganu, Liz Segedin, Luregn Schlapbach, Gary Williams, Frank Shann, Warwick Butt for the Paediatric Study Group and Australian and New Zealand Intensive Care Society.

Critical Care Medicine, Sep 2015.
Health-related quality of life in survivors of acute kidney injury: The Prolonged Outcomes Study of the Randomized Evaluation of Normal versus Augmented Level Replacement Therapy study outcomes.

Wang AY, Bellomo R, Cass A, Finfer S, Gattas D, Myburgh J, Chadban S, Hirakawa Y, Ninomiya T, Li Q, Lo S, Barzi F, Sukkar L, Jardine M, Gallagher MP; POST-RENAL Study Investigators and the ANZICS Clinical Trials Group.

Nephrology (Carlton). 2015 Jul;20(7):492-8. doi: 10.1111/nep.12488. PubMed PMID: 25891297.
Hypothermia for Traumatic Brain Injury in Children (HiTBIC) – A Phase II Randomized Controlled Trial.

John Beca, Brent McSharry, Simon Erickson, Michael Yung, Andreas Schibler, Anthony Slater, Barry Wilkins, Peter Skippen, Gary Williams, Claire Sherring, Warwick Butt for the Paediatric Study Group of the Australian and New Zealand Intensive Care Society Clinical Trials Group.

Critical Care Medicine, Jul 2015.
Protocol for a multicentre randomised controlled trial of early and sustained prophylactic hypothermia in the management of traumatic brain injury.

Nichol A, Gantner D, Presneill J, Murray L, Trapani T, Bernard S, Cameron P, Capellier G, Forbes A, McArthur C, Newby L, Rashford S, Rosenfeld JV, Smith T, Stephenson M, Varma D, Walker T, Webb S, Cooper DJ.

Crit Care Resusc. 2015 Jun;17(2):92-100. PMID: 26017126
Intensive versus conventional glucose control in critically ill patients with traumatic brain injury: long-term follow-up of a subgroup of patients from the NICE-SUGAR study.

NICE-SUGAR Study Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group and the Canadian Critical Care Trials Group.

Intensive Care Med. 2015 Jun;41(6):1037-47. doi: 10.1007/s00134-015-3757-6. Epub 2015 Jun 19. PMID: 26088909
The timing of discharge from the intensive care unit and subsequent mortality. A prospective, multicenter study.

Santamaria JD, Duke GJ, Pilcher DV, Cooper DJ, Moran J, Bellomo R; Discharge and Readmission Evaluation (DARE) Study.

Am J Respir Crit Care Med. 2015 May 1;191(9):1033-9. doi: 10.1164/rccm.201412-2208OC. PMID: 25730675
Stress ulcer prophylaxis in the intensive care unit: an international survey of 97 units in 11 countries.

Krag M, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S, McArthur C, Cook D, Nielsen N, Pelosi P, Keus F, Guttormsen AB, Moller AD, Møller MH; SUP-ICU Collaborators.

Acta Anaesthesiol Scand. 2015 May;59(5):576-85. doi: 10.1111/aas.12508. PMID: 25880349
Overview of the study protocols and statistical analysis plan for the Saline versus Plasma-Lyte 148 for Intravenous Fluid Therapy (SPLIT) research program.

Reddy SK, Young PJ, Beasley RW, Mackle DM, McGuinness SP, McArthur CJ, Henderson SJ, Weinberg L, French CJ, Orford NR, Bailey MJ, Bellomo R.

Crit Care Resusc. 2015 Mar;17(1):29-36. PMID: 25702759
Elevated plasma-free cortisol concentrations and ratios are associated with increased mortality even in the presence of statin therapy in patients with severe sepsis.

Venkatesh B, Imeson L, Kruger P, Cohen J, Jones M, Bellomo R; Australian and New Zealand Intensive Care Society Clinical Trials Group; STATInS Trial Investigators.

Crit Care Med. 2015 Mar;43(3):630-5. doi: 10.1097/CCM.0000000000000750. PMID: 25513788
Erythropoietin in traumatic brain injury: study protocol for a randomised controlled trial.

Nichol A, French C, Little L, Presneill J, Cooper DJ, Haddad S, Duranteau J, Huet O, Skrifvars M, Arabi Y, Bellomo R; EPO-TBI Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Trials.

2015 Feb 8;16:39. doi: 10.1186/s13063-014-0528-6. PMID: 25884605
Early mobilization and recovery in mechanically ventilated patients in the ICU: a bi-national, multi-centre, prospective cohort study.

TEAM Study Investigators, Hodgson C, Bellomo R, Berney S, Bailey M, Buhr H, Denehy L, Harrold M, Higgins A, Presneill J, Saxena M, Skinner E, Young P, Webb S.

Crit Care. 2015 Feb 26;19:81. doi: 10.1186/s13054-015-0765-4. PMID: 25715872
Mortality related to invasive infections, sepsis, and septic shock in critically ill children in Australia and New Zealand, 2002-13: a multicentre retrospective cohort study.

Schlapbach LJ, Straney L, Alexander J, MacLaren G, Festa M, Schibler A, Slater A; ANZICS Paediatric Study Group.

Lancet Infect Dis. 2015 Jan;15(1):46-54. doi: 10.1016/S1473-3099(14)71003-5. Epub 2014 Dec 1.
Resuscitation fluid use in Australian and New Zealand intensive care units between 2007 and 2013

Hammond NE, Taylor C, Saxena M, Liu B, Finfer S, Glass P, Seppelt I, Willenberg L, Myburgh J for the George Institute for Global Health and the Australian and New Zealand Intensive Care Society Clinical Trials Group

Intens Care Med, 2015, 41(9):1611-9, doi: 10.1007/s00134-015-3878-y. PMID: 26077073
2014
Economic evaluation of the prophylaxis for thromboembolism in critical care trial (E-PROTECT): study protocol for a randomized controlled trial.

Fowler RA, Mittmann N, Geerts WH, Heels-Ansdell D, Gould MK, Guyatt G, Krahn M, Finfer S, Pinto R, Chan B, Ormanidhi O, Arabi Y, Qushmaq I, Rocha MG, Dodek P, McIntyre L, Hall R, Ferguson ND, Mehta S, Marshall JC, Doig CJ, Muscedere J, Jacka MJ, Klinger JR, Vlahakis N, Orford N, Seppelt I, Skrobik YK, Sud S, Cade JF, Cooper J, Cook D; Canadian Critical Care Trials Group and the Australia and New Zealand Intensive Care Society Clinical Trials Group.

Trials. 2014 Dec 20;15(1):502. doi: 10.1186/1745-6215-15-502. PMID: 25528663
Statistical analysis plan for the Erythropoietin in Traumatic Brain Injury trial: a randomised controlled trial of erythropoietin versus placebo in moderate and severe traumatic brain injury.

Presneill J, Little L, Nichol A, French C, Cooper DJ, Haddad S, Duranteau J, Huet O, Skrifvars M, Arabi Y, Bellomo R, and EPO-TBI Study Investigators on behalf of the ANZICS-Clinical Trials Group.

Trials 2014, 15:501
The IRONMAN trial: a protocol for a multicentre randomised placebo-controlled trial of intravenous iron in intensive care unit patients with anaemia.

Litton E, Baker S, Erber W, French C, Ferrier J, Hawkins D, Higgins AM, Hofmann A, Keulenaer BL, Farmer S, McMorrow J, Olynyk J, Richards T, Towler S, Webb S; Australian and New Zealand Intensive Care Society Clinical Trials Group.

Crit Care Resusc. 2014 Dec;16(4):285-90. PMID: 25437223
A randomised controlled trial of standard transfusion versus fresher red blood cell use in intensive care (TRANSFUSE): protocol and statistical analysis plan.

Kaukonen KM, Bailey M, Ady B, Aubron C, French C, Gantner D, Irving D, Murray L, Nichol A, Pettilä V, McQuilten Z, Cooper DJ.

Crit Care Resusc. 2014 Dec;16(4):255-61. PubMed PMID: 25437218.
Mortality related to invasive infections, sepsis, and septic shock in critically ill children in Australia and New Zealand, 2002-13: a multicentre retrospective cohort study.

Schlapbach LJ, Straney L, Alexander J, MacLaren G, Festa M, Schibler A, Slater A; ANZICS Paediatric Study Group.

Lancet Infect Dis. 2015 Jan;15(1):46-54. doi: 10.1016/S1473-3099(14)71003-5. Epub 2014 Dec 1. PMID: 25471555
Prediction of death in less than 60 minutes after withdrawal of cardiorespiratory support in potential organ donors after circulatory death.

Brieva J1, Coleman N, Lacey J, Harrigan P, Lewin TJ, Carter GL.

Transplantation. 2014 Nov 27;98(10):1112-8. doi: 10.1097/TP.0000000000000186.
Cost-effectiveness of dalteparin vs unfractionated heparin for the prevention of venous thromboembolism in critically ill patients.

Fowler RA, Mittmann N, Geerts W, Heels-Ansdell D, Gould MK, Guyatt G, Krahn M, Finfer S, Pinto R, Chan B, Ormanidhi O, Arabi Y, Qushmaq I, Rocha MG, Dodek P, McIntyre L, Hall R, Ferguson ND, Mehta S, Marshall JC, Doig CJ, Muscedere J, Jacka MJ, Klinger JR, Vlahakis N, Orford N, Seppelt I, Skrobik YK, Sud S, Cade JF, Cooper J, Cook D; Canadian Critical Care Trials Group; Australia and New Zealand Intensive Care Society Clinical Trials Group.

JAMA. 2014 Nov 26;312(20):2135-45. doi: 10.1001/jama.2014.15101. PMID: 25362228
Procalcitonin Algorithm in Critically Ill Adults with Undifferentiated Infection or Suspected Sepsis: A Randomized Controlled Trial.

Yahya Shehabi, Martin Sterba, Peter Maxwell Garrett, Kanaka Sundaram Rachakonda, Dianne Stephens, Peter Harrigan, Alison Walker, Michael J Bailey, Bronwyn Johnson, David Millis, Geoff Ding, Sandra Peake, Helen Wong, Jane Thomas, Kate Smith, Loretta Forbes, Miranda Hardie, Sharon Micallef, John F Fraser, the ProGUARD Study Investigators and the ANZICS Clinical Trials Group.

Am J Respir Crit Care Med. First published online 8 Oct 2014 as DOI: 10.1164/rccm.201408-1483OC.
Goal-directed resuscitation for patients with early septic shock.

ARISE Investigators; ANZICS Clinical Trials Group, Peake SL, Delaney A, Bailey M, Bellomo R, Cameron PA, Cooper DJ, Higgins AM, Holdgate A, Howe BD, Webb SA, Williams P.

N Engl J Med. 2014 Oct 16;371(16):1496-506. doi: 10.1056/NEJMoa1404380. Epub 2014 Oct 1.
Angiotensin-converting enzyme inhibitor usage and acute kidney injury: a secondary analysis of RENAL study outcomes.

Wang AY, Bellomo R, Ninomiya T, Lo S, Cass A, Jardine M, Gallagher M; RENAL Study Investigators; ANZICS Clinical Trials Group.

Nephrology (Carlton). 2014 Oct;19(10):617-22. doi: 10.1111/nep.12284. PMID: 24894685
Understanding the global epidemiology of pediatric critical illness: the power, pitfalls, and practicalities of point prevalence studies.

Weiss SL, Fitzgerald JC, Faustino EV, Festa MS, Fink EL, Jouvet P, Bush JL, Kissoon N, Marshall J, Nadkarni VM, Thomas NJ; Pediatric Acute Lung Injury and Sepsis Investigators Network and Australia and New Zealand Intensive Care Society Investigators.

Pediatr Crit Care Med. 2014 Sep;15(7):660-6. doi: 10.1097/PCC.0000000000000156.
Individual patient data comparative analysis of hydroxyethyl starch 130/0.4 v 4% albumin for fluid resuscitation in critically ill patients: statistical analysis plan.

Hammond NE, Billot L, Finfer S, Myburgh J.

Crit Care Resusc. 2014 Sep;16(3):206-13. PMID: 25161024
Timing of renal replacement therapy and patient outcomes in the randomized evaluation of normal versus augmented level of replacement therapy study.

Jun M, Bellomo R, Cass A, Gallagher M, Lo S, Lee J; Randomized Evaluation of Normal Versus Augmented Level of Replacement Therapy (RENAL) Study Investigators.

Crit Care Med. 2014 Aug;42(8):1756-65. doi: 10.1097/CCM.0000000000000343. PMID: 24717460
Use of a concentrated enteral nutrition solution to increase calorie delivery to critically ill patients: a randomized, double-blind, clinical trial.

Peake SL, Davies AR, Deane AM, Lange K, Moran JL, O'Connor SN, Ridley EJ, Williams PJ, Chapman MJ; TARGET investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group.

Am J Clin Nutr. 2014 Aug;100(2):616-25. doi: 10.3945/ajcn.114.086322. Epub 2014 Jul 2. PMID: 24990423
2013
Paediatric index of mortality 3: an updated model for predicting mortality in pediatric intensive care*.

Straney L, Clements A, Parslow RC, Pearson G, Shann F, Alexander J, Slater A; ANZICS Paediatric Study Group and the Paediatric Intensive Care Audit Network.

Pediatr Crit Care Med. 2013 Sep;14(7):673-81. doi: 10.1097/PCC.0b013e31829760cf.
Acute Risk Change: An innovative measure of operative adverse events and perioperative team performance.

TG Coulson, B Gregson, S Sandys, S Nashef, S Webb, M Bailey, C Reid, D Pilcher.

Journal of Cardiothoracic and Vascular Anesthesia
Admission to Intensive Care for Palliative Care or Potential Organ Donation: Demographics, Circumstances, Outcomes, and Resource Use.

Melville A, Kolt G, Anderson D, Mitropoulos J, Pilcher D.

Crit Care Med. 2017 Aug 11;
Age and other perioperative risk factors for postoperative systemic inflammatory response syndrome after cardiac surgery.

Dieleman JM, Peelen LM, Coulson TG, Tran L, Reid CM, Smith JA, Myles PS, Pilcher D.

British Journal of Anaesthesia 2017 Oct; 119 (4): 637–644
Adverse outcomes after planned surgery with anticipated intensive care admission in out-of-office-hours time periods: a multicentre cohort study.

Morgan DJ, Ho KM, Kolybaba ML, Ong YJ; ANZICS Centre for Outcome and Resource Evaluation.

Br J Anaesth. 2018 Jun;120(6):1420-1428.
Association of Hypercapnia and Hypercapnic Acidosis With Clinical Outcomes in Mechanically Ventilated Patients With Cerebral Injury.

Tiruvoipati R, Pilcher D, Botha J, Buscher H, Simister R, Bailey M.

JAMA Neurol. 2018 Mar
Central line-associated bloodstream infections in Australian ICUs: evaluating modifiable and non-modifiable risks in Victorian healthcare facilities.

Spelman T, Pilcher DV, Cheng AC, Bull AL, Richards MJ, Worth LJ.

Epidemiol Infect. 2017 Sep 4:1-9.
Characteristics, incidence, and outcome of patients admitted to the intensive care unit with myasthenia gravis.

Al-Bassam W, Kubicki M, Bailey M, Walker L, Young P, Pilcher DV, et al.

J Crit Care. 2018 Jan 7;45:90–4.
Declining mortality in critically ill patients with cirrhosis in Australia and New Zealand between 2000 and 2015.

Majumdar A, Bailey M, Kemp WM, Bellomo R, Roberts SK, Pilcher D.

J Hepatol. 2017 Aug 9;
Early glycemia and mortality in critically ill septic patients: Interaction with insulin-treated diabetes.

Magee F, Bailey M, Pilcher DV, Mårtensson J, Bellomo R.

J Crit Care. 2018 Mar 3;45:170–1.
Early, Goal-Directed Therapy for Septic Shock – A Patient-Level Meta-Analysis.

PRISM Investigators, Rowan KM, Angus DC, Bailey M, Barnato AE, Bellomo R, Canter RR, Coats TJ, Delaney A, Gimbel E, Grieve RD, Harrison DA, Higgins AM, Howe B, Huang DT, Kellum JA, Mouncey PR, Music E, Peake SL, Pike F, Reade MC, Sadique MZ, Singer M, Yealy DM.

N Engl J Med. 2017 Jun 8;376(23):2223-2234. doi: 10.1056/NEJMoa1701380. Epub 2017 Mar 21. PubMed PMID: 28320242.
Early Hyperoxia in Patients with Traumatic Brain Injury Admitted to Intensive Care in Australia and New Zealand: A Retrospective Multicenter Cohort Study.

Ó Briain D, Nickson C, Pilcher DV, Udy AA.

Neurocrit Care. 2018 Jun 8.
Effect of a National Standard for Deteriorating Patients on Intensive Care Admissions Due to Cardiac Arrest in Australia.

Jones D, Bhasale A, Bailey M, Pilcher D, Anstey MH.

Crit Care Med. 2018 Apr;46(4):586–93.
Hypercapnia and hypercapnic acidosis in sepsis: harmful, beneficial or unclear?

Tiruvoipati R, Gupta S, Pilcher D, Bailey M.

Crit Care Resusc. 2018 Jun;20(2):94-100.
ICU Admissions for Sepsis or Pneumonia in Australia and New Zealand in 2017

Burrell A, Huckson S, Pilcher DV; ANZICS.

N Engl J Med. 2018 May 31;378(22):2138-2139.
Identification and assessment of potentially high-mortality intensive care units using the ANZICS Centre for Outcome and Resource Evaluation clinical registry.

McClean K, Mullany D, Huckson S, Lint A van, Chavan S, Hicks P, et al.

Crit Care Resusc. 2017 Sep;19(3):230–8.
Intensity of early correction of hyperglycaemia and outcome of critically ill patients with diabetic ketoacidosis.

Mårtensson J, Bailey M, Venkatesh B, Pilcher D, Deane A, Abdelhamid YA, Crisman M, Verma B, MacIsaac C, Wigmore G, Shehabi Y, Suzuki T, French C, Orford N, Kakho N, Prins J, Ekinci EI, Bellomo R.

Crit Care Resusc. 2017 Sep;19(3):266-273.
Intensive care discharge delay is associated with increased hospital length of stay: A multicentre prospective observational study.

Tiruvoipati R, Botha J, Fletcher J, Gangopadhyay H, Majumdar M, Vij S, Paul E, Pilcher D; Australia and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group.

PLoS One. 2017 Jul 27;12(7):e0181827. doi: 10.1371/journal.pone.0181827. eCollection 2017. PubMed PMID: 28750010; PubMed Central PMCID: PMC5531506.
Maintenance Fluid Practices in Intensive Care Units in Australia and New Zealand

Bihari S, Watts NR, Seppelt I, Thompson K, Myburgh A, Prakash S and Bersten A for the George Institute of Global Health and the ANZICS Clinical Trials Group

Critical Care Resusc, 2016 Jun;18(2):89-94. PMID: 27242106
Paediatric sequential organ failure assessment score (pSOFA): a plea for the world-wide collaboration for consensus.

Kawasaki T, Shime N, Straney L, Bellomo R, MacLaren G, Pilcher D, et al.

Intensive Care Med. 2018 Apr 27;
Patient characteristics, incidence, technique, outcomes and early prediction of tracheostomy in the state of Victoria, Australia.

A Casamento, M Bailey, R Robbins, D Pilcher, S Warrillow, A Ghosh, R Bellomo.

Journal of critical care 44, Dec 17, 278-284,
Patterns of intravenous fluid resuscitation use in adult intensive care patients between 2007 and 2014: An international cross-sectional study.

Hammond NE, Taylor C, Finfer S, Machado FR, An Y, Billot L, Bloos F, Bozza F, Cavalcanti AB, Correa M, Du B, Hjortrup PB, Li Y, McIntryre L, Saxena M, Schortgen F, Watts NR, Myburgh J; Fluid-TRIPS and Fluidos Investigators; George Institute for Global Health, The ANZICS Clinical Trials Group, BRICNet, and the REVA research Network.

PLoS One. 2017 May 12;12(5):e0176292. doi: 10.1371/journal.pone.0176292. eCollection 2017. PubMed PMID: 28498856; PubMed Central PMCID:​ PMC5428917.
Patterns of organ donation in children in Australia and New Zealand.

Corkery-Lavender T, Millar J, Cavazzoni E, Gelbart B.

Crit Care Resusc. 2017 Dec;19(4):296-302.
Predicting Expected Organ Donor Numbers in Australian Hospitals Outside of the Donate-Life Network Using the Anzics Adult Patient Database.

O’Brien Y, Chavan S, Huckson S, Russ G, Opdam H, Pilcher D.

Transplantation. 2018 Feb
Prognostic accuracy of age-adapted SOFA, SIRS, PELOD-2, and qSOFA for in-hospital mortality among children with suspected infection admitted to the intensive care unit.

Schlapbach LJ, Straney L, Bellomo R, MacLaren G, Pilcher D.

Intensive Care Med. 2017 Dec 19.
Protocol and statistical analysis plan for the Randomised Evaluation of Active Control of Temperature versus Ordinary Temperature Management (REACTOR) trial.

Young PJ, Bailey MJ, Beasley RW, Freebairn RC, Hammond NE, Haren FM, Harward ML, Henderson SJ, Mackle DM, McArthur CJ, McGuinness SP, Myburgh JA, Saxena MK, Turner A, Webb SA, Bellomo R; The ANZICS Clinical Trials Group.

Crit Care Resusc. 2017 Mar;19(1):81-87. PubMed PMID: 28215136.
Sample size calculations for cluster randomised crossover trials in Australian and New Zealand intensive care research.

Arnup SJ, McKenzie JE, Pilcher D, Bellomo R, Forbes AB.

Crit Care Resusc. 2018 Jun;20(2):117-123.
Statistical analysis plan for the Adjunctive Corticosteroid Treatment in Critically Ill Patients with Septic Shock (ADRENAL) trial.

Billot L, Venkatesh B, Myburgh J, Finfer S, Cohen J, Webb S, McArthur C, Joyce C, Bellomo R, Rhodes A, Perner A, Arabi Y, Rajbhandari D, Glass P, Thompson K, Correa M, Harward M.

Crit Care Resusc. 2017 Jun;19(2):183-191. PubMed PMID: 28651515.
The association between peri-operative acute risk change (ARC) and long-term survival after cardiac surgery.

Coulson TG, Bailey M, Reid CM, Tran L, Mullany DV, Smith JA, et al.

Anaesthesia. 2017 Jul 13;
The Melbourne epidemic thunderstorm asthma event 2016: an investigation of environmental triggers, effect on health services, and patient risk factors.

Thien F, Beggs PJ, Csutoros D, Darvall J, Hew M, Davies JM, et al.

Lancet Planet Health. 2018 Jun;2(6)
The systemic inflammatory response syndrome criteria and their differential association with mortality.

Kaukonen K-M, Bailey M, Pilcher D, Cooper DJ, Bellomo R.

J Crit Care. 2018 Apr 7;46:29–36.
Understanding the cluster randomised crossover design: a graphical illustraton of the components of variation and a sample size tutorial.

Arnup SJ, McKenzie JE, Hemming K, Pilcher D, Forbes AB.

Trials. 2017 Aug 15;18(1):381.
Which organ dysfunction scores to use in children with infection?

Leclerc F, Duhamel A, Leteurtre S, Straney L, Bellomo R, MacLaren G, et al.

Intensive Care Med. 2018 Mar 22